The world's first shampoo with caffeine from certified organic coffee strengthens hair roots and re-activates circulation in the scalp.
Pure plant cleansing agents guarantee mild yet thorough cleansing. Menthol generates a refreshing cooling effect.
DIRECTIONS FOR USE: Apply to wet hair and massage in. Leave on the scalp for TWO minutes for optimal effects. This two minute period is crucial, and studies indicate that this is the optimal minimum time for the caffeine to be absorbed by the hair follicle. Rinse and repeat if desired. SLS free.
Caffeine from organic coffee beans is the key active component in For Him ReActivate Shampoo. Its efficacy for hair loss prevention is based on an in-vitro study done where follicles were treated with a caffeine solution. It was found that caffeine blocks the effects of DHT, the hormone that causes Male Pattern Baldness and damages the hair follicles
Dr Fischer, who conducted the first trial, took scalp biopsies from 14 men in the early stages of hair loss. He extracted the hair follicles and then placed them in test tubes with solutions containing different levels of caffeine.
The follicles that were being treated with caffeine saw their average growth increase by around 46% and the life cycle of the hair extended by 37%, when compared to the control group.
In the study, researchers in Germany wanted to see if topically applied caffeine could be delivered to the follicle when being part of a shampoo.
According to the study it was possible to prove that after 2 minutes of shampooing, the caffeine in the shampoo was able to penetrate into the scalp via the hair follicles and stratum corneum (the outermost layer of the skin), proving that shampoo is an effective delivery vehicle for caffeine, provided that its left on the scalp for 2 minutes or more.
Aims: Follicular drug delivery is the prerequisite for an effective treatment of androgenetic alopecia or other reasons of premature hair loss.
Methods: The follicular penetration of caffeine, applied topically in a shampoo formulation for 2 minutes, was measured with highly sensitive surface ionization in combination with mass spectroscopy, a selective method for the detection of very small quantities of transcutaneously absorbed substances in the blood. An experimental protocol, developed to selectively block the follicular pathway within the test area, was used. Based on this principle, a clear distinction between interfollicular and follicular penetration of topically applied caffeine was feasible.
Results: After 2 minutes, caffeine penetrated via the hair follicles and stratum corneum.
Conclusion: It was found that the penetration via hair follicles was faster and higher compared with the interfollicular route and that hair follicles are the only pathway for fast caffeine absorption during the first 20 minutes after application.
Copyright (c) 2007 S. Karger AG, Basel. Source: PMID 17396054.